COVID-19

Hronologija negiranja "efekta Leonardi", hipoteze o slabljenju imuno sistema posle kovida:
https://thetyee.ca/Analysis/2022/11/07/COVID-Reinfections-And-Immunity

The record shows that Leonardi has been remarkably prescient, constant and often correct. Yes, his thesis about exhausted T cells and immune dysfunction still remain a working hypothesis. Still, there is much evidence that the virus is causing widespread immune dysregulation in both mild and severe cases.
Herd immunity, as Leonardi predicted, remains a fiction.
Reinfections have been associated with worrisome outcomes in a highly touted study.
The Leonardi Effect may well explain a surge in bacterial, viral and fungal infections after waves of COVID. The risks to children remain grave in the absence of masks and good air filtration and ventilation.
As he sees such findings accumulate, how does Leonardi feel? “Disappointed, because most scientists did not fully appreciate the likelihood of such rapid antigenic evolution, so now we are awash with a deadly virus with many disabled, and it will continue to bring more people to their knees,” he told The Tyee.
He does not know when the pandemic will end. He suspects an excellent nasal spray vaccine combined with long-term changes to public infrastructure to clean the air could reduce COVID’s menace.

Efekat je nazvan po istraživaču sa John Hopkinsa koji je prvi 2020. postavio tu hipotezu (kada su neki ugledniji imunolozi virolozi još uvek verovali da je moguć imunitet krda za ovaj virus):
https://www.frontiersin.org/articles/10.3389/fimmu.2020.600405/full

Nije bio jedini, virolog William Haseltine je pisao slična upozorenja da je nemoguć imunitet krda za koronaviruse tokom 2020.:
https://www.project-syndicate.org/c...defeat-covid19-by-william-a-haseltine-2020-10
 
Zoran Radovanović :
https://www.danas.rs/vesti/drustvo/...ili-kako-treba-a-naredna-je-pitnanje-vremena/

Epidemiolog Zoran Radovanović, koji je nedavno predstavio knjigu „Kovid 19 – pandemija između nauke i politike“, kaže da je bilo potrebno ostaviti pisani trag, jer, kako navodi, već možemo da podvučemo crtu i vidimo da smo loše prošli u pandemiji.
Epidemiolog je podsetio da je višak smrtnosti u svetu najveći u Bugarskoj pa onda u Srbiji i dodao da neko mora da podnese odgovornost, kao i da izvučemo pouke iz nesreće. „Zašto smo loše prošli, nismo radili kako treba, ako ne izvučemo pouke nastradaćemo u narednoj, a naredna je pitanje vremena. Jasno je ako dozvolite da lekari o tome govore biće kritični, moraće da se govori o problemima, visokoj smrtnosti“, istakao je on za N1.




Kod Galeba:

 
Sharon Stone se, kao sada onkoloski bolesnik, zarazila COVID-om od medicinske sestre.

Uspela je da se ne zarazi do sada a onda ode da se leci od raka i pokupi Koronu od medicinskog osoblja koje nije htelo da nosi masku jer, dakako, "COVID je sada smesna i blaga bolest".

Sad pored tumora, vec 16 dana se bori i sa Koronom. Za onkoloske bolesnike, posebno ako je vec i terapija krenula, i prehlada moze biti kobna a kamoli Korona.

Strasno je zaista sve ovo i prodavanje zdravlja zarad malo zabave u kaficima i turizma.

https://www.hellomagazine.com/healt...t-doctors-unfortunate-news-fans-send-support/
 

Lepo je što doktorka objašnjava kako posle kovida vide povećan rizik od ostalih infekcija (mogla je da izgovori i oslabljen imunitet), ali je sumanuto da se i dalje propagira pranje ruku kao prva zaštita protiv respiratornih bolesti (obzirom da znamo da se prenose vazduhom), a nošenje maske samo u slučaju bolesti (tj. simptoma), kad znamo da je polovina transmisije asimptomatska...
 
Otkrića iz obdukcija:

We find evidence of viral presence in the lung up to 359 days after the acute phase of disease, including in patients with negative nasopharyngeal swab tests.
The fact that in our data we find the level of vascular derangement higher in post-acute than in *acute* COVID-19 suggests that vascular remodeling is a continuously acting process during post-acute COVID disease

https://t.co/0EjHjO1vY2


Posledice po muški reproduktivni sistem:

https://onlinelibrary.wiley.com/doi/10.1002/jmv.27971

https://pubmed.ncbi.nlm.nih.gov/33125771/

https://fortune.com/2022/08/17/long-covid-erectile-dysfunction-link-pandemic-health-carolyn-barber/

https://pubmed.ncbi.nlm.nih.gov/34931145
 
U Kini je jedan čovek napolju u parku za pola sata zarazio 35 ljudi, od toga jednog sa maskom (pretpostavljam da je bila hirurška).

Neke omikron varijante su postale toliko zarazne da se lako šire napolju u prolaznom kontaktu :(

https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2022.209

Of the 2,836 people potentially exposed in the park, 39 tested SARS-CoV-2 positive. Gene analysis from the 39 cases showed highly homologous when compared to Patient Zero. Epidemiological investigations supported that Patient Zero transmitted to the following 33 visitors and 2 park cleaners and the 2 cleaners transmitted to 4 colleagues. This outbreak indicated that the Omicron subvariant BA.2.76 could be easily transmitted to others outdoors if they are not equipped with effective protection equipment.
Close contacts were persons who have a distance of less than 1 meter with Patient Zero and without effective prevention measures. At-risk populations were persons who had been to areas that Patient Zero visited while without close contact with Patient Zero. Close contacts were quarantined at hotels for 7 days and at-risk populations were quarantined at home for 3 days. Finally, 256 close contacts and 20,496 at-risk populations were identified. Health personnel took daily throat swab for SARS-CoV-2 nucleic acid PCR tests for them.
On August 16, Patient Zero entered the park through the east gate at 6:54 am, jogged counterclockwise to the lake and circled the lake 4 times. He left the park along the same roads at the east gate at 07:29. The path width of jogging was about 4 meters. The wind speed was 0.5–3.0 m/s, the temperatures were 33.0℃–42℃ and the air humidity was 44%–48% when Patient Zero was jogging. The east gate of the park is the main gate, with convenient transportation, and a good flow of people. During the jogging time, there were 104 close contacts who have a distance less than 1 meter with Patient Zero and without wearing masks.
 
Evo i jedne uslovno receno lepe vesti.....

Rezim ishrane poznat kao intermittent fasting snizava rizik od najgorih komplikacija COVIDa, hospitalizacije i smrti.

Inace, meni je ovo savrseno imalo smisla od pocetka ali nisam hteo nista da spominjem dok se makar neki rad time ne pozabavi ali ako se pravilno radi, IF snizava inflamaciju i samim tim sprecavamo scenario u kojem dolazi do hiperinflamacije kao rezultata infekcije, a samim tim se snizava i verovatnoca najgorih ishoda. A besplatno je.

Cisto anegdotalno da dodam u ovom kontekstu, ja sam praktikujem fasting vec godinama i to je deo mog...da kazemo, rezima za snizavanje rizika od bolesti (onih najgorih) na najmanju mogucu meru. 16 sati ne unosim kalorije, 8 sati unosim i tako skoro svaki dan. Naravno, i vakcinisan sam tri puta. COVID u akutnoj fazi skoro prosao asimptomatski kod mene i u tom periodu nisam radio IF. Nakon prelezane Korone, bio sam iscrpljen onako kako inace i biva nakon virusne infekcije (a posebno ove) i imao sam neke sitne simptome tipa bolovi u misicima koji su nastavili da traju i nakon COVIDa kako sam ranije i pisao.

Medjutim, kad sam poceo da se vracam na moj uobicajeni 16:8 rezim, ovi simptomi su vremenom poceli da slabe a sad funkcionisem kao da nikad nisam imao COVID i, da cuknem u drvo, nakon 9 meseci ne osecam nikakve posledice.

Bilo bi dobro da se uradi jos radova na ovu temu ali definitivno fasting u kombinaciji sa vakcinacijom moze da bude potencijalno jako dobar combo za snizavanje rizika od long COVIDa i svih najgorih posledica Korone. Zato je potrebno jos istrazivanja.

Fasting nije za svakoga doduse, nazalost, ali eto i moje licno iskustvo se poklapa sa zakljucima autora ove studije. Iako ja doduse nisam radio IF "decenijama" ali i 5 godina je nekog efekta imalo.

https://www.pharmacytimes.com/view/...iated-with-less-severe-covid-19-complications
People who regularly fast are less likely to experience severe complications from COVID-19 (SARS-CoV-2), according to a recent study published in BMJ Nutrition, Prevention & Health.

COVID-19 patients who practiced regular water-only intermittent fasting were found to have lower risk of hospitalization or death due to the virus compared with patients who did not. Previous research has identified health benefits of intermittent fasting, including lowered risk of diabetes and heart disease, according to the study authors.

“Intermittent fasting has already shown to lower inflammation and improve cardiovascular health. In this study, we’re finding additional benefits when it comes to battling an infection of COVID-19 in patients who have been fasting for decades,” said Benjamin Horne, PhD, director of cardiovascular and genetic epidemiology at Intermountain Healthcare, in a statement.
 
16 sati ne unosim kalorije, 8 sati unosim i tako skoro svaki dan.
Zanimljivo.
Je l' to znači da preskačeš doručak ili večeru, ili spakuješ sva tri obroka u 8 sati (recimo od 10 ujutru do 6 uveče)?


Moj suprug često ume da preskoči ručak i da ništa ne jede nekih 12 sati tokom dana, što je mene inače brinulo. Moram da mu kažem da to možda i nije loše, da možda smanjuje infekcije, i rizik od dijabetesa i bolesti srca...
 
Zanimljivo.
Je l' to znači da preskačeš doručak ili večeru, ili spakuješ sva tri obroka u 8 sati (recimo od 10 ujutru do 6 uveče)?


Moj suprug često ume da preskoči ručak i da ništa ne jede nekih 12 sati tokom dana, što je mene inače brinulo. Moram da mu kažem da to možda i nije loše, da možda smanjuje infekcije, i rizik od dijabetesa i bolesti srca...

Da, ja licno (uglavnom) ne doruckujem, preskocim dorucak ali uredno rucam i veceram ali moze i da se preskoci vecera, a moze i da se nista ne preskoci ali samo da se vodi racuna da sve sto se kalorijski unese u toku dana bude u sklopu tih 8 sati.
I upravo je to zapravo stos. Dakle, mi unesemo sve ono sto bi inace uneli i da nemamo to vremensko ogranicenje (naravno, podrazumeva se da bi trebali da izbegavamo junk food, secer u ogromnoj kolicini i slicno....), jedemo normalno, ali smo "period hranjenja" ogranicili na 8 sati. Nema grickanja svakih sat vremena ili (najgora varijanta) otvaranja frizidera iza ponoci da "se nesto prezalogaji uz seriju".....nego kad se uzme zadnji obrok, nema jela do sledeceg dana.

Ja recimo veceram oko 8 i tu se moje jelo zavrsava za taj dan, do podneva sutradan nema jela. U medjuvremenu moze da se pije voda, caj, pa cak i kafa ali je bitno da ne unosimo kalorije putem recimo nekih zasladjivaca jer cim krene da se luci insulin, fasting je prekinut.

E sad, sta se u stvari desava u telu (ukratko) u tom periodu kad ne jedemo. Kad ne unosimo hranu izmedju 12 i 16 sati (a optimalno oko 16), aktivira se proces autofagije i dolazi do reciklaze starih, ostecenih i disfunkcionalnih celija a onda se ta energija koristi za formiranje novih, mladih i zdravih celija. Cak se i maligne celije (koje se inace svaki dan stvaraju u nasem telu po defaultu) razgradjuju u tom procesu. Pored toga, smanjuju se upalni procesi u organizmu i aktiviraju se Sirtuin geni, odnosni geni za dugovecnost. Ovi geni su prisutni kod svakoga i aktiviraju se kad je organizam u stanju stresa, a jedan takav stres je upravo (privremeno) gladovanje. Fizicka aktivnost ih takodje aktivira. A kad jedemo svakih sat vremena recimo, kad imamo sedentarni stil zivota.......onda su i ovi geni u fazonu "nema potrebe da mi ista radimo, mozemo slobodno da se iskljucimo". Ovako, kad je telo u nekom (blazem) stresu, onda se ti geni aktiviraju jer je neophodno preziveti.

Fasting je jako dobar nacin da, pre svega preventivno, delujemo na pojavu maltene svih teskih hronicnih bolesti koje su manje ili vise usko vezane za starenje pocevsi od kardiovaskularnih bolesti, dijabetesa (tip 2), pa sve do kancera. I zaista, svi dokazi koje za sada imamo idu u prilog tome da fasting smanjuje rizik od dobijanja ovih bolesti.

Jos jedna stvar tu mora da se spomene i da se osvrne na AMPK i mTOR. Kada nam je AMPK aktiviran, mTOR nije i obratno a recimo u studijama se videlo da kod bolesti tipa kancer (najidealniji primer), AMPK je inhibiran dok je mTOR "hiperaktivan". Kada recimo gladujemo ili kad smo fizicki aktivni, onda se mTOR iskljucuje a AMPK se aktivira i deluje anti-kancerogeno + anti-inflamatorno. mTOR je dobar za nas.......dok smo jos u periodu razvoja. Ali onda kad smo vec formirani ljudi, e tada zeli da nas ubije i unisti. Tada doprinosi recimo proliferaciji celija.......sto je potpis kancera. Tako da je u stvari idealno da AMPK aktiviramo sto vise mozemo a mTOR-u da ne dozvolimo da "luduje" i tu takodje fasting jako pomaze. Jer samo preko IF-a recimo dolazimo u situaciju da je AMPK aktivan 16 sati, dok mTOR radi svega 8.

Inace, postoje i neki lekovi koji su vec na trzistu i imaju isto ovo dejstvo kao fasting ali se pomenuti mehanizmi aktiviraju bez gladovanja. I sad trenutno su studije u toku a rezultati su vrlo obecavajuci. Mislim da smo blizu trenutka kada cemo stvarno konacno moci da imamo kontrolu nad nasim zdravljem i to ce nam pre svega omoguciti nove i savremene terapije. Ali dok taj trenutak ne dodje, IF je jako korisna stvar.
 
But imprinting does seem to have dashed the hope that the introduction of variant-targeted mRNA boosters will provide greater protection against infection than sticking with the original vaccine. Boosters introduced in Europe last September targeted the original strain and the BA.1 Omicron variant; the United States has rolled out boosters aimed at the BA.5 Omicron variant. The vaccines certainly boost antibody levels, but the antibodies produced are not Omicron specific and are unlikely to offer significantly increased protection against Omicron infection
https://www.nature.com/articles/d41586-023-00086-1


Šteta što nismo iskorenili kovid dok su vakcine sprečavale infekciju...
 
Astmatičari ipak jesu rizična grupa, u smislu da im kovid pogoršava astmu:
People with asthma in Hong Kong experienced worse control of their asthma after they had recovered from mild to moderate COVID-19, according to findings yesterday in Respiratory Research.

For the case-control study, researchers with the University of Hong Kong enrolled 111 people with asthma who had experienced mild to moderate COVID-19 from 30 to 270 days before enrollment and 110 asthma patients who hadn't had COVID.

They used the Asthma Control Test (ACT) for quantifying asthma control. An ACT score of 25 indicates complete asthma control, 20 to 24 indicates well-controlled asthma, 17 to 19 not well-controlled asthma, and 16 or less poorly controlled asthma. The investigators determined that a drop of 3 ACT points or more indicates less asthma control.
https://t.co/4b2bEXmg6r


Naučna istina se polako probija na NBC:


Nadam se da neće trebati 50 godina kao za azbest i pušenje...
 
Već duže se sumnja da je SARS2 perzistentan virus...
Izgleda da slabi mukozni imunitet 😞



Long COVID: The Persistence of SARS-CoV-2 in the Mucous Membranes May Be A Factor
https://presse.inserm.fr/en/covid-l...s-les-muqueuses-pourrait-etre-en-cause/66975/



Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response
In summary, our study indicates that PASC is defined by persisting immunological dysfunction as late as six months following SARS-CoV-2 infection, including alterations in mucosal immune parameters, redistribution of mucosal CD8+β7Integrin+ T cells and IgA, indicative of potential viral persistence and mucosal involvement in the etiopathology of PASC.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061413/
 
Dabogda sve izgorelo ako se vrati ovo.
 
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